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Начинается пандемия чумы, известная как Юстинианова чума, которая свирепствует по всему Средиземнморью на протяжении более двух столетий и ослабляет Византию, унося ежедневно жизни 10 000 человек в Константинополе в своем пике

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Европа

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Death came in some cases immediately, in others after many days; and with some the body broke out with black pustules about as large as a lentil and these did not survive even one day, but all succumbed immediately. With many also a vomiting of blood ensued without visible cause and straightway brought death. Moreover I am able to declare this, that the most illustrious physicians predicted that many would die, who unexpectedly escaped entirely from suffering shortly afterwards, and that they declared that many would be saved, who were destined to be carried off almost immediately.

Secret History by Procopius

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